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Biotransformation and Metabolite Elucidation of Xenobiotics: Characterization and Identification
Ala F. Nassar
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Description for Biotransformation and Metabolite Elucidation of Xenobiotics: Characterization and Identification
Hardcover. Considerable attention has been focused recently on the potential role of human drug metabolites in drug safety and on how to provide a risk assessment for these molecules using preclinical safety models. Editor(s): Nassar, Ala F. Num Pages: 328 pages, Illustrations. BIC Classification: PSAG. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly. Dimension: 233 x 164 x 23. Weight in Grams: 644.
The goal of this book is to improve the readers' knowledge of metabolite elucidation in drug metabolism by exposing them to in depth coverage of the biotransformation of xenobiotics, strategies for identifying and characterizing metabolites, FDA guidelines, and case studies on how to improve the decision-making process in structural modification of drug candidates to reduce toxicity.
The goal of this book is to improve the readers' knowledge of metabolite elucidation in drug metabolism by exposing them to in depth coverage of the biotransformation of xenobiotics, strategies for identifying and characterizing metabolites, FDA guidelines, and case studies on how to improve the decision-making process in structural modification of drug candidates to reduce toxicity.
The book consists of 8 chapters; it first provides an introduction on biotransformation of xenobiotics, and then presents modern approaches and strategies for dealing with metabolite characterization, using tools such as LC-MS, H-D exchange, stable isotopes LC-MS-NMR, and radiolabeled compounds. Also, strategies for ... Read more
Show LessProduct Details
Format
Hardback
Publication date
2010
Publisher
John Wiley & Sons Inc United Kingdom
Number of pages
328
Condition
New
Number of Pages
344
Place of Publication
New York, United States
ISBN
9780470504789
SKU
V9780470504789
Shipping Time
Usually ships in 7 to 11 working days
Ref
99-50
About Ala F. Nassar
ALA F. NASSAR, PHD, has worked in the pharmaceutical industry for more than ten years. For over five years, Dr. Nassar oversaw the drug metabolism and bioanalytical department at Vion Pharmaceuticals, working in these key areas of drug discovery and development. One principal area of his research involved understanding how structure modification can improve the ADME profile for new chemical ... Read more
Reviews for Biotransformation and Metabolite Elucidation of Xenobiotics: Characterization and Identification
"Contributors mostly from pharmaceutical companies provide a systematic introduction to characterizing metabolites, which has become an important element in drug discovery. They write for scientists involved in designing, developing, and advancing metabolic characterizations for drug discovery and development, and for researchers and students in fields that might call for such characterizations." (Book News Inc., February 2011)