Pharmacokinetics and Metabolism in Drug Design
Douglas A. Smith
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Description for Pharmacokinetics and Metabolism in Drug Design
Hardback. A concise introduction to the parameters and processes governing the absorption, distribution and retention of drug compounds in the body, now expanded to cover prodrugs, antitumor drugs and predictive approaches. Editor(s): Smith, Dennis A.; Allerton, Charlotte; Kubinyi, Hugo; Waterbeemd, Han van de; Walker, Han; Walker, Don K.; Kalgutkar, Amit S. Series Editor(s): Mannhold, Raimund; Kubinyi, Hugo; Folkers, Gerd. Series: Methods and Principles in Medicinal Chemistry. Num Pages: 268 pages, Illustrations. BIC Classification: MMG; TDCW. Category: (P) Professional & Vocational. Dimension: 247 x 174 x 18. Weight in Grams: 660.
In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the previous chapter layout has been retained, substantial revisions have been made, with new topics such as pro-drugs, active metabolites and transporters covered in detail in a manner useful to the Drug Discovery scientist. The authors discuss the parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts.
While aimed ... Read more
In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the previous chapter layout has been retained, substantial revisions have been made, with new topics such as pro-drugs, active metabolites and transporters covered in detail in a manner useful to the Drug Discovery scientist. The authors discuss the parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts.
While aimed ... Read more
Product Details
Format
Hardback
Publication date
2012
Publisher
Wiley-VCH Verlag GmbH Germany
Number of pages
268
Condition
New
Series
Methods and Principles in Medicinal Chemistry
Number of Pages
268
Place of Publication
Berlin, Germany
ISBN
9783527329540
SKU
V9783527329540
Shipping Time
Usually ships in 4 to 8 working days
Ref
99-1
About Douglas A. Smith
Dennis Smith worked in the pharmaceutical industry for more than 30 years since gaining his PhD from the University of Manchester (UK). He worked at Pfizer Global R & D at Sandwich for 24 years, with the role of Vice President for Pharmacokinetics, Dynamics and Metabolism. During his career he directly contributed to the Discovery and Development of eight NCEs. ... Read more
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