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Bioisosteres in Medicinal Chemistry
Nathan Brown
€ 160.40
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Description for Bioisosteres in Medicinal Chemistry
Hardback. Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. Editor(s): Brown, Nathan. Series Editor(s): Mannhold, Raimund; Kubinyi, Hugo; Folkers, Gerd. Series: Methods and Principles in Medicinal Chemistry. Num Pages: 256 pages, Illustrations (some col.). BIC Classification: MMG; TDCW. Category: (P) Professional & Vocational. Dimension: 248 x 173 x 16. Weight in Grams: 632.
Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.
As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.
The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered,
while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part
covers the four key methodologies for bioisostere identification and replacement: physicochemical ... Read more
Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.
As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.
The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered,
while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part
covers the four key methodologies for bioisostere identification and replacement: physicochemical ... Read more
Product Details
Publisher
Wiley-VCH Verlag GmbH Germany
Number of pages
256
Format
Hardback
Publication date
2012
Series
Methods and Principles in Medicinal Chemistry
Condition
New
Weight
631g
Number of Pages
256
Place of Publication
Berlin, Germany
ISBN
9783527330157
SKU
V9783527330157
Shipping Time
Usually ships in 4 to 8 working days
Ref
99-2
About Nathan Brown
Nathan Brown is the Head of the In Silico Medicinal Chemistry group in the Cancer Therapeutics Unit at The Institute of Cancer Research in London (UK). At the ICR, Nathan and his group support our entire drug discovery portfolio together with developing new computational methodologies to enhance our drug design work. Nathan conducted his doctoral research in Sheffield with ... Read more
Reviews for Bioisosteres in Medicinal Chemistry
“In all, I believe this book is a musthave handbook on bioisosteres. It is highly valuable both as a text book for graduate students and as a book of reference for the medicinal chemist working in the industry as well as in an academic setting.” (ChemMedChem, 1 July 2013)