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Jose V. Bonilla (Ed.) - Handbook of Analysis of Oligonucleotides and Related Products - 9781138198456 - V9781138198456
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Handbook of Analysis of Oligonucleotides and Related Products

€ 98.39
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Description for Handbook of Analysis of Oligonucleotides and Related Products Paperback. Editor(s): Bonilla, Jose V.; Srivatsa, G. Susan. Num Pages: 511 pages, 266 black & white illustrations, 76 black & white tables. BIC Classification: MBGR; PNF; PSD; TCB. Category: (G) General (US: Trade); (U) Tertiary Education (US: College). Dimension: 176 x 246 x 38. Weight in Grams: 892.

Oligonucleotides represent one of the most significant pharmaceutical breakthroughs in recent years, showing great promise as diagnostic and therapeutic agents for malignant tumors, cardiovascular disease, diabetes, viral infections, and many other degenerative disorders. The Handbook of Analysis of Oligonucleotides and Related Products is an essential reference manual on the practical application of modern and emerging analytical techniques for the analysis of this unique class of compounds. A strong collaboration among thirty leading analytical scientists from around the world, the book provides readers with a comprehensive overview of the most commonly used analytical techniques and their advantages and limitations in assuring ... Read more

Topics discussed include:

  • Strategies for enzymatic or chemical degradation of chemically modified oligonucleotides toward mass spectrometric sequencing
  • Purity analysis by chromatographic or electrophoretic methods, including RP-HPLC, AX-HPLC, HILIC, SEC, and CGE
  • Characterization of sequence-related impurities in oligonucleotides by mass spectrometry and chromatography
  • Structure elucidation by spectroscopic methods (IR, NMR, MS) as well as base composition and thermal melt analysis (Tm)
  • Approaches for the accurate determination of molar extinction coefficient of oligonucleotides
  • Accurate determination of assay values
  • Assessment of the overall quality of oligonucleotides, including microbial analysis and determination of residual solvents and heavy metals
  • Strategies for determining the chemical stability of oligonucleotides
  • The use of hybridization techniques for supporting pharmacokinetics and drug metabolism studies in preclinical and clinical development
  • Guidance for the presentation of relevant analytical information towards meeting current regulatory expectations for oligonucleotide therapeutics

This resource provides a practical guide for applying state-of-the-art analytical techniques in research, development, and manufacturing settings.

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Product Details

Publication date
Taylor & Francis Ltd
Signed by the author
Number of Pages
Place of Publication
London, United Kingdom
Shipping Time
Usually ships in 4 to 8 working days

About Jose V. Bonilla (Ed.)
Dr. Jose V. Bonilla’s career has been dedicated to the introduction and implementation of cutting-edge analytical technologies such as LC-MS, high-speed gas chromatography, high-speed GPC, online GC, online HPLC, and online near-IR. He has extensive experience in the management of industrial and pharmaceutical analytical laboratories in compliance with regulatory requirements and is the author and coauthor of several peer-reviewed publications. ... Read more

Reviews for Handbook of Analysis of Oligonucleotides and Related Products
This is a unique resource for guiding the analysis of oligonucleotide-based drug products. No other single source provides such a comprehensive overview of the necessary analytical techniques that assess the qualitative characteristics of oligonucleotides intended for pharmaceutical use. —Rachel R Chennault, Ph.D.(American College of Clinical Pharmacy), in Doody's Notes

Goodreads reviews for Handbook of Analysis of Oligonucleotides and Related Products

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