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Each of the 13 chapters authored by experts in the respective fields is clearly and consistently structured, providing a detailed outline of pathogenesis as a rational basis for recommended investigations and management of specific conditions. Pathophysiological considerations are comprehensive and incorporate recent advances such as the increased understanding of the neurochemical basis of secondary brain injury and the association between specific apolipoprotein E genotypes and an increased risk of Alzheimer’s disease following head trauma. Recommended diagnostic strategies are clearly outlined and advantages and limitations of specific investigations are discussed in the context of each clinical scenario. Numerous tables throughout the text (for example on investigation of stroke, delirium and neuromuscular disorders associated with respiratory paralysis) allow for easily accessible and concise reference.