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Tumour Hypoxia: Molecular Mechanisms and Clinical Implications
Silvia Pastorekova
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Description for Tumour Hypoxia: Molecular Mechanisms and Clinical Implications
Hardback. .
Insufficient supply of oxygen, i.e. hypoxia, typically occurs in a broad range of solid tumours due to aberrant vasculature. It is a key component of tumour microenvironment that affects many biological processes at molecular, cellular and tissue levels. Adaptive responses to oxygen deficiency shape signal transduction, cell metabolism, proliferation, differentiation, survival, angiogenesis, immunosurveillance etc. and thereby contribute to tumour invasion and metastasis. Presence of tumour hypoxia is significantly associated with poor prognosis and therapy resistance. Therefore, it represents a clinically relevant phenomenon that can be exploited for improvement of existing diagnostic and treatment procedures as well as for development of ... Read more
Insufficient supply of oxygen, i.e. hypoxia, typically occurs in a broad range of solid tumours due to aberrant vasculature. It is a key component of tumour microenvironment that affects many biological processes at molecular, cellular and tissue levels. Adaptive responses to oxygen deficiency shape signal transduction, cell metabolism, proliferation, differentiation, survival, angiogenesis, immunosurveillance etc. and thereby contribute to tumour invasion and metastasis. Presence of tumour hypoxia is significantly associated with poor prognosis and therapy resistance. Therefore, it represents a clinically relevant phenomenon that can be exploited for improvement of existing diagnostic and treatment procedures as well as for development of ... Read more
Product Details
Publisher
Peter Lang AG
Format
Hardback
Publication date
2012
Series
Spectrum Slovakia
Condition
New
Number of Pages
556
Place of Publication
Bern, Switzerland
ISBN
9783631639917
SKU
V9783631639917
Shipping Time
Usually ships in 4 to 8 working days
Ref
99-1
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